Buffalo & Brule Region
Where the prairie meets adventure and history.
Explore by Category
Businesses in Buffalo & Brule Region
362 local businesses serving the community.
Agtegra Cooperative Chamberlain
Agtegra provides comprehensive solutions for farmers, including crop protection, grain marketing, and more. Trust us to be your reliable agricultural partner.
Agtegra Cooperative Kimball Agronomy
Retail
Akta Lakota Museum
Discover Lakota history and culture at the Aktá Lakota Museum & Cultural Center through storytelling, exhibits, and educational resources.
Allen's South Dakota Fishing and Hunting Lodge
Retail
AmericInn Lodge and Suites with Convention Center of Chamberlain
Hospitality
AmericInn by Wyndham Chamberlain Conference Center
Hospitality
American Creek Campground
Enjoy spending time with family and friends as you relax along the shores of the Missouri River.
About Buffalo & Brule Region
Buffalo & Brule Region is the cultural and economic heart of the area. A vibrant mix of historic architecture, world-class dining, and thriving local businesses.
Own a business here?
Claim your free listing or upgrade to stand out to thousands of loyal locals every day.
Claim Your Business